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KMID : 0358119880140010035
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Journal of the Korean Public Health Association
1988 Volume.14 No. 1 p.35 ~ p.45
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CELL SIZE HETEROGENEITY DUE TO ANTICANCER DRUG WHICH MIGHT INDICATE RESISTANCE
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Abstract
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Drug resistance of P 815 mouse tumor cells after various drug treatments was studied by scoring the changes of cell sizes. Percent of cells with abnormal large cell size (larger than 15um in diameter) increased by treatment of anticancer drugs.
When the cells were treated with adriamycin, cells larger than l5pm in diameter were observed at second day post-treatment and the percent of larger cells reached maximum at 9th day post-treatment. Similar trends were observed following the treatment with cisplatin, 5-Fu, or methotrexate. Inverse relationship between survival of tumor cell population and percent distribution of large cells was observed when cisplatin was treated. Thus it was suggested that co-existence of abnormal large cells and cells in original size in the tumor cell population after drug treatment might be a key to determine that the cell line
is resistant which thereby indication for next drug of choice.
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KEYWORD
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